CD80 Antigen

The CD80 antigen (B7, BB1) is a highly glycosylated single-chain protein. Its extracellular domain consists of two Ig-like domains. This 60 kDa molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes after 24h stimulation and at maximal level 48-72h post activation. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells and activated monocytes. CD80 binding provides co-stimulatory signals for T cell activation.


 Clone: MAB104  Isotype: IgG1 Mouse

The MAB104 monoclonal antibody reacts with in vitro activated B lymphocytes, some B cell lines, and weakly with a small proportion of non-activated B cells. This antibody also reacts with activated T cells but not with peripheral monocytes and T cells.
 



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Product Line Specifications

Формат Liquid
Specificity CD80
Form APC-Alexa Fluor* 750
Clone MAB104
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B30643

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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