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The CD23 antigen (also called B6) is a transmembrane glycoprotein with a molecular weight of 45 kDa, spatially associated with the major histocompatibility complex (MHC) Class II antigen. The CD23 molecule, also named FcεRII is the low affinity receptor for IgE. CD23 antigen is primarily expressed on B lymphocytes and monocytes. It is also present on a large variety of other cells such as T lymphocytes, eosinophils, platelets, Langerhans cells, follicular dendritic cells (FDC), a subset of thymic epithelial cells and neutrophils. On B lymphocytes, CD23 expression is up-regulated upon activation and ultimately lost upon differentiation towards secreting-plasmocytes. A soluble form of CD23 (sCD23) exists and may be involved (like CD23) in the regulation of IgE synthesis and inflammatory phenomenom.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
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