Beta2-Microglobulin Antigen
The β2-microglobulin is the non-polymorphic non-covalently bound light chain (12 kDa) of the class I major histocompatibility complex (MHC-I) constitutively expressed on the surface of almost all nucleated cell. β2-microglobulin structure, stabilized by a disulfide bound, is similar to an immunoglobulin like domain. β2-microglobulin is required in the endoplasmic reticulum (ER) to associate with the MHC class I heavy molecule to form with other proteins (calreticulin, tapasin, etc.) the loading complex that exits the ER and is transported to the cell surface. After peptide presentation, β2-microglobulin is actively released into circulation.
| Clone: B1G6 | Isotype: IgG2a Mouse |
| The B1G6 monoclonal antibody is specific for human β2-microglobulin. It does not react with β2-microglobulin from other species. It recognizes the β2-microglobulin, free or associated with human HLA class I molecules. | |
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Product Line Specifications
| Формат | Freeze-dried |
| Specificity | β2-microglobulin |
| Form | UNLB |
| Clone | B1G6 |
| Isotype | IgG2a Mouse |
| Item Specifications Referenced | IM0114 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.