Lineage-PE Cocktail, 100 Tests, RUO

B29559


The Lineage-PE Cocktail is comprised of PE-conjugated CD3, CD14, CD19, CD20 and CD56 antibodies. It enables the positive staining of five immune cell populations (T and B Lymphocytes, NK cells, Monocytes/Macrophages) together, without distinction, in the PE channel using flow cytometry. When combined with fluorescent-labeled antibodies, other than PE, the gating on PE negative cells allows the phenotypical identification of Dendritic cells. The CD20 molecule is expressed on B lineage cells. Its CD20 expression occurs early in pre-B lymphocyte development, persists throughout B lymphocyte ontogeny and is lost upon ultimate plasma cells differentiation. The CD20 molecule is present on all B lymphocytes whatever the hematopoietic tissue where they are found (peripheral blood, lymph nodes, spleen, tonsil, or bone marrow). CD20 is also expressed, but at low density, on a subset of peripheral blood T lymphocytes. The CD56 molecule, known as NCAM (Neural Cell Adhesion Molecule) antigen, is expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with natural killer (NK) activity. It is also expressed by a minor subpopulation of CD3+ T cells that mediates reduced cytotoxic activity. It is not found on monocytes, granulocytes, erythrocytes or B lymphocytes. The CD20 molecule is expressed on B lineage cells. Its CD20 expression occurs early in pre-B lymphocyte development, persists throughout B lymphocyte ontogeny and is lost upon ultimate plasma cells differentiation. The CD20 molecule is present on all B lymphocytes whatever the hematopoietic tissue where they are found (peripheral blood, lymph nodes, spleen, tonsil, or bone marrow). CD20 is also expressed, but at low density, on a subset of peripheral blood T lymphocytes. The CD56 molecule, known as NCAM (Neural Cell Adhesion Molecule) antigen, is expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with natural killer (NK) activity. It is also expressed by a minor subpopulation of CD3+ T cells that mediates reduced cytotoxic activity. It is not found on monocytes, granulocytes, erythrocytes or B lymphocytes.

Технические спецификации

Целевой вид Человек
Регуляторный статус RUO
Размер 100 Tests

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Что означает регулярный статус продукта:
IVD: In Vitro Diagnostic. Данная продукция предназначена для клинической диагностики in vitro.
ASR: Analyte Specific Reagents. Специфические аналитические реагенты. Аналитические и технические характеристики не установлены.
CE: Продукция, предназначенная для клинической диагностики in vitro и соответствующая директиве Европейского союза (98/79/EC). (Примечание: Оборудование может соответствовать другим директивам Европейского союза, и иметь соответствующую маркировку.)
RUO: Research Use Only. Данная продукция предназначена только для научных исследований и не предназначена для клинической диагностики.
LUO: Laboratory Use Only. Продукция предназначены только для лабораторного использования.
Без регуляторного статуса: немедицинские изделия и изделия, не подлежащие обязательной регистрации в регуляторных органах. Данная продукция не предназначена для клинического применения.